The trial will test multiple drugs simultaneously. It will test two repurposed medicines used to treat type 2 diabetes. Study will examine whether drugs can lessen memory and thinking problems.
AD-SMART is a multi-arm trial where several treatments are tested. The approach has been successfully used in cancer, motor neurone disease. Atomoxetine and metformin may help reduce brain inflammation.
1,200 people with mild to moderate dementia will be recruited at 30 sites across the UK. Scientists expect to finish evaluating first drugs in 2030. All the participants will have health checks including cognitive tests.
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