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THE GUARDIAN · HEALTH · October 20, 2026

Australian researchers identify new subtype of depression linked to body clock disruptions

THE SHORT VERSION

Circadian depression affects nearly a quarter of 11,000 participants. Study identifies subtype of depression linked to disruptions in body's internal clock. Researchers believe it is less responsive to antidepressant treatments. People affected by subtype may benefit from treatments targeting circadian rhythms.

Circadian depression has more severe mental health symptoms, researchers say. The age of onset of the depression was younger compared to non-circadian depression. Circadians also had more episodes and also complex trajectories and more suicidality.

Behavioural neuroscientist says depression is linked to changes in body clock. He cites a lack of detail as to how cluster of features was arrived at. The findings are best interpreted as initial, if interesting findings.

Read the full story on The Guardian · Health

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